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SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Vitamin D3 aids liver health
Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.
Relevant to cirrhosis treatment
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
Read More
9
Vitamin D3's role in liver health
Vitamin D supplementation alleviates high fat diet-induced metabolic associated fatty liver disease by inhibiting ferroptosis pathway.
High relevance for liver disease
We explored the potential of vitamin D3 in mitigating liver disease associated with a high-fat diet. In our study, male mice were placed on a high-fat diet for 16 weeks while receiving regular vitamin D3 injections. This setup allowed us to effectively gauge the compound's impact on liver health.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
Read More
9
Vitamin D3 aids in liver fat reduction
Vitamin D 1,25-Dihydroxyvitamin D reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization.
High relevance to liver disease
We explored how vitamin D3 impacts non-alcoholic fatty liver disease (NAFLD) and its influence on liver immune cells. In an exciting study, researchers set up an experiment using mice on a high-fat diet to create a model of NAFLD. The mice received 1,25-dihydroxyvitamin D, a potent form of vitamin D3, to see if it could counteract the detrimental effects of fatty liver condition.
The findings were promising. The treatment improved liver fat levels and enhanced lipid metabolism. It achieved this, in part, by reversing the polarization of inflammatory immune cells in the liver. Specifically, the vitamin D3 appeared to lower the presence of pro-inflammatory M1 macrophages, which are linked to greater liver fat accumulation. The research suggested that vitamin D3 works through specific pathways in the body, hinting at its potential as a helpful supplement for individuals struggling with liver fat issues.
Overall, this study highlights the therapeutic promise of 1,25(OH)D for improving liver health in the context of obesity-related conditions. While there’s more to uncover, the results offer hope for better management strategies for NAFLD in the future.
The findings were promising. The treatment improved liver fat levels and enhanced lipid metabolism. It achieved this, in part, by reversing the polarization of inflammatory immune cells in the liver. Specifically, the vitamin D3 appeared to lower the presence of pro-inflammatory M1 macrophages, which are linked to greater liver fat accumulation. The research suggested that vitamin D3 works through specific pathways in the body, hinting at its potential as a helpful supplement for individuals struggling with liver fat issues.
Overall, this study highlights the therapeutic promise of 1,25(OH)D for improving liver health in the context of obesity-related conditions. While there’s more to uncover, the results offer hope for better management strategies for NAFLD in the future.
Read More
Most Useful Reviews
9.5
Essential for thyroid
Having thyroid diseases, vitamin D is an essential daily supplement for me. It's crucial because Hashimoto's autoimmune thyroiditis is linked to vitamin D deficiency. It aids calcium absorption and contributes to the health of the thyroid, skin, hair, and nails. We take it daily and I highly recommend it!
Read More
9.5
Reduced stiffness
I've been taking Now Foods vitamins Vitamin D-3 5000 IU for two years. After switching from alfacalcidol, recommended by my doctor for osteoporosis, the results were evident in just two weeks. The stiffness in my movements alleviated, and the pain diminished significantly. These vitamins have truly transformed my life!
Read More
9.5
Alleviated tooth pain
Vitamin D deficiency can lead to various health issues, especially concerning the immune system and teeth. I took a substantial dose of 5,000,000 units for a severe toothache. Remarkably, the pain lessened within two days. A lower dose would not have sufficed for my condition.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
9
Vitamin D3 aids liver health
Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.
Relevant to cirrhosis treatment
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
Read More
9
Vitamin D3's role in liver health
Vitamin D supplementation alleviates high fat diet-induced metabolic associated fatty liver disease by inhibiting ferroptosis pathway.
High relevance for liver disease
We explored the potential of vitamin D3 in mitigating liver disease associated with a high-fat diet. In our study, male mice were placed on a high-fat diet for 16 weeks while receiving regular vitamin D3 injections. This setup allowed us to effectively gauge the compound's impact on liver health.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
As we examined the results, we observed that vitamin D3 supplementation notably reduced weight gain and improved liver function in these mice. Beyond mere weight management, vitamin D3 also showed promising effects on serum lipid levels and insulin sensitivity, key metrics related to liver health.
Even more encouraging, we found that vitamin D3 helped inhibit harmful processes in liver cells, particularly ferroptosis, which is a type of cell death associated with many liver diseases. It achieved this by enhancing antioxidant capacity and regulating iron levels within the liver. These findings were further validated using human liver cells treated with a saturated fat equivalent, reinforcing the compound's potential as a supportive treatment for liver issues.
Overall, our research suggests that vitamin D3 holds promise for improving liver health and could be a valuable addition to treatment strategies for fatty liver disease, particularly in populations at risk.
Read More
9
Calcitriol mitigates liver toxicity
Calcitriol ameliorates cisplatin-induced hepatorenal toxicity via regulation of Nrf2-Mrp2/p38 MAPK signaling in mice.
Moderate relevance due to combined treatment
We examined the potential of calcitriol, also known as vitamin D3, to protect the liver from damage caused by cisplatin, a commonly used chemotherapy drug. In this study, mice were split into groups to assess the effects of calcitriol alone, cisplatin alone, and the combination of both. Notably, calcitriol was given to some mice leading up to the administration of cisplatin.
Our observations showed that calcitriol significantly helped in reversing the liver damage induced by cisplatin. This was noticeable through improved liver and kidney function tests, as well as better histological results. Additionally, calcitriol appeared to reduce oxidative stress and inflammation in both the liver and kidneys while enhancing the expression of certain protective proteins.
We also noted that calcitriol played a role in lowering inflammation markers and promoting cell survival by downregulating harmful proteins. Interestingly, when calcitriol was given alongside cisplatin, the liver's resilience against cisplatin's toxic effects was markedly enhanced. Overall, our findings suggest that calcitriol may offer a protective strategy against liver damage caused by chemotherapy, primarily through its anti-inflammatory and antioxidant properties.
Our observations showed that calcitriol significantly helped in reversing the liver damage induced by cisplatin. This was noticeable through improved liver and kidney function tests, as well as better histological results. Additionally, calcitriol appeared to reduce oxidative stress and inflammation in both the liver and kidneys while enhancing the expression of certain protective proteins.
We also noted that calcitriol played a role in lowering inflammation markers and promoting cell survival by downregulating harmful proteins. Interestingly, when calcitriol was given alongside cisplatin, the liver's resilience against cisplatin's toxic effects was markedly enhanced. Overall, our findings suggest that calcitriol may offer a protective strategy against liver damage caused by chemotherapy, primarily through its anti-inflammatory and antioxidant properties.
Read More
9
Vitamin D3 aids in liver fat reduction
Vitamin D 1,25-Dihydroxyvitamin D reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization.
High relevance to liver disease
We explored how vitamin D3 impacts non-alcoholic fatty liver disease (NAFLD) and its influence on liver immune cells. In an exciting study, researchers set up an experiment using mice on a high-fat diet to create a model of NAFLD. The mice received 1,25-dihydroxyvitamin D, a potent form of vitamin D3, to see if it could counteract the detrimental effects of fatty liver condition.
The findings were promising. The treatment improved liver fat levels and enhanced lipid metabolism. It achieved this, in part, by reversing the polarization of inflammatory immune cells in the liver. Specifically, the vitamin D3 appeared to lower the presence of pro-inflammatory M1 macrophages, which are linked to greater liver fat accumulation. The research suggested that vitamin D3 works through specific pathways in the body, hinting at its potential as a helpful supplement for individuals struggling with liver fat issues.
Overall, this study highlights the therapeutic promise of 1,25(OH)D for improving liver health in the context of obesity-related conditions. While there’s more to uncover, the results offer hope for better management strategies for NAFLD in the future.
The findings were promising. The treatment improved liver fat levels and enhanced lipid metabolism. It achieved this, in part, by reversing the polarization of inflammatory immune cells in the liver. Specifically, the vitamin D3 appeared to lower the presence of pro-inflammatory M1 macrophages, which are linked to greater liver fat accumulation. The research suggested that vitamin D3 works through specific pathways in the body, hinting at its potential as a helpful supplement for individuals struggling with liver fat issues.
Overall, this study highlights the therapeutic promise of 1,25(OH)D for improving liver health in the context of obesity-related conditions. While there’s more to uncover, the results offer hope for better management strategies for NAFLD in the future.
Read More
9
Vitamin D3 impacts AIH outcomes
Autoimmune Hepatitis and Vitamin D Deficiency: A Nationwide Perspective.
Highly relevant study insights
We set out to understand how vitamin D3 affects individuals with autoimmune hepatitis (AIH). Our retrospective cohort study gathered data from the vast TriNetX research network, focusing on patients diagnosed with AIH. Participants were categorized based on their vitamin D levels: sufficient, insufficient, and deficient.
Our analysis revealed some concerning findings. We observed that those with vitamin D deficiency had significantly higher odds of all-cause mortality compared to patients with normal levels. This translated to a 3.2 times increase in the likelihood of death. Additionally, vitamin D deficiency was linked to higher rates of hospitalization, critical care admissions, decompensated liver cirrhosis, acute liver failure, and even the need for liver transplants.
Quite simply, vitamin D deficiency appears to negatively influence the health outcomes of patients with AIH. Our research suggests that maintaining adequate vitamin D levels could be crucial for individuals suffering from this liver condition.
Our analysis revealed some concerning findings. We observed that those with vitamin D deficiency had significantly higher odds of all-cause mortality compared to patients with normal levels. This translated to a 3.2 times increase in the likelihood of death. Additionally, vitamin D deficiency was linked to higher rates of hospitalization, critical care admissions, decompensated liver cirrhosis, acute liver failure, and even the need for liver transplants.
Quite simply, vitamin D deficiency appears to negatively influence the health outcomes of patients with AIH. Our research suggests that maintaining adequate vitamin D levels could be crucial for individuals suffering from this liver condition.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.9
9.5
Essential for thyroid
Having thyroid diseases, vitamin D is an essential daily supplement for me. It's crucial because Hashimoto's autoimmune thyroiditis is linked to vitamin D deficiency. It aids calcium absorption and contributes to the health of the thyroid, skin, hair, and nails. We take it daily and I highly recommend it!
Read More
9.5
Reduced stiffness
I've been taking Now Foods vitamins Vitamin D-3 5000 IU for two years. After switching from alfacalcidol, recommended by my doctor for osteoporosis, the results were evident in just two weeks. The stiffness in my movements alleviated, and the pain diminished significantly. These vitamins have truly transformed my life!
Read More
9.5
Alleviated tooth pain
Vitamin D deficiency can lead to various health issues, especially concerning the immune system and teeth. I took a substantial dose of 5,000,000 units for a severe toothache. Remarkably, the pain lessened within two days. A lower dose would not have sufficed for my condition.
8.8
Improved skin condition
I have skin problems, along with other health issues, and taking vitamin D at the correct dosage as advised by my doctor has been beneficial. I have idiopathic urticaria, and this supplement has improved my skin condition. I've resumed taking it as my levels dropped, which needs monitoring. This product has helped me significantly.
Read More
5.5
Increased vitamin levels
Continuing this supplement has increased my vitamin D levels. However, long-term use might strain the liver, so it’s wise to stay below 5000 IU.
